Examination of the relationship between EGFR mutant allele frequency and efficacy of EGFR inhibitor of tissue samples and blood samples in patient with lung cancer

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K21688
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics; Tumor therapeutics
• Research Institution: Shizuoka Cancer Center Research Institute
• Principal Investigator: Akira Ono 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (50441027)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 肺癌 / リキッドバイオプシー / allele frequency

Outline of Final Research Achievements

Ultrasensitive EGFR gene mutation measuring system was constructed using tissue samples and blood samples in non-small cell lung cancer patients.This result is significant in realizing quantification of EGFR gene mutation with non-invasive methoed. With development future genome medicine, we considered important in evaluating choice of treatment policy and efficacy of treatment based on the evaluation of allele frequency in EGFR gene mutation and other somatic gene mutataion.

Free Research Field

臨床腫瘍学

Academic Significance and Societal Importance of the Research Achievements

侵襲性の低い血液検体での遺伝子検査方法の確立が、今後のがんゲノム医療の発展に寄与し得ると考える。