2018 Fiscal Year Final Research Report
Analysis of human sarcoma stem cells and memory T stem cells
| Project/Area Number |
16H05451
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 肉腫幹細胞 / 免疫記憶幹細胞 / 代謝 / 癌抗原 |
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| Outline of Final Research Achievements |
We identified sarcoma stem cell antigen LIN28B which conferred higher tumor-initiating ability and chemo-resistance to osteosarcoma stem cells. LIN28B suppressed OXPHOS and increased glycolysis dependency in osteosarcoma stem cells. Glycolysis inhibitors could suppress in vitro tumorigenesis of osteosarcoma stem cells.
We also identified a novel human memory T stem cells, "Young Memory T cells". Young memory T cells showed the chemo-resistance, differentiation capacity and superior growth ability upon T cell receptor stimulation. T cells recognizing anti-viral antigen and anti-tumor-associated antigen could be induced from young memory T cells derived from sarcoma patients who received high-dose chemotherapy.
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| Free Research Field |
がん免疫，骨軟部腫瘍
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| Academic Significance and Societal Importance of the Research Achievements |
骨肉腫をはじめとする高い悪性形質を示す肉腫は時に若年者に発症し，化学療法不応例症例の予後は不良である．本研究成果により，解糖系阻害によって腫瘍増殖能が抑制される可能性，抗がん剤の効果が増強される可能性が示唆された．
また免疫記憶幹細胞を制御できれば，がんワクチンやT細胞移入療法による免疫治療の効果をより高められる可能性がある．
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