Effects and Safety of Oral Mast Cells Stabilization Therapy in Early Dengue Patients: A Randomized, Placebo-Controlled Trial

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05844
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: NGUYEN Huytien 長崎大学, 熱帯医学・グローバルヘルス研究科, 准教授 (20457526)
• Co-Investigator(Kenkyū-buntansha): ローサボーン チャントラ 長崎大学, 熱帯医学研究所, 教授 (10640196)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: デング / 血漿漏出 / 超音波 / 診断 / アレルギー

Outline of Final Research Achievements

We have already finished a systematic review to optimize a standardized ultrasound to measure the plasma leakage in dengue patients that is the main indicator of dengue severity. A clinical study has been conducted to assess the reproducibility of US in the assessment of gallbladder-wall thickness in addition to the volume of pleural effusion and ascites as a consequence of plasma leakage in dengue children. Our results showed that ultrasound values of plasma leakage were highly reproducible and showed a good intra- and inter-observer agreement between ultrasonic doctors.

Free Research Field

感染症内科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、デング熱の診断とその重症度を予測する超音波検査の標準化手法を確立した。本手法は臨床医師の診断に役立つことが期待される。我々は既に本手法のパイロット試験を行った。臨床応用のためには更に臨床試験を繰り返す必要がある。