2018 Fiscal Year Final Research Report
Tumor blood vessel formaiton by "vascular strand invasion"
| Project/Area Number |
16H06147
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
HAYASHI Yumiko
MURAMATSU Fumitaka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 腫瘍血管形成 / 血管移動 / 生体イメージング |
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| Outline of Final Research Achievements |
Tumor blood vessels that supply the oxygen and nutrients to tumor tissues are necessary for tumor growth. Therefore, anti-angiogenic therapy has been considered promising therapeutic strategy for cancer treatment because inhibition of angiogenesis contributes to tumor progression. However, anti-angiogenic drug such as VEGF (Vascular endothelial growth factor) inhibitor have not bring remarkable therapeutic effects. In this study, we conducted research aimed at elucidating the Mechanisms of acquired resistance to anti-angiogenic therapy. As a result, we found a novel mechanism to acquire new tumor blood vessels by the movement of vessels. Moreover, we discovered that myeloid cell subsets are involved in the regulation of this phenomenon.
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| Free Research Field |
血管生物医学
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| Academic Significance and Societal Importance of the Research Achievements |
血管を介した酸素や栄養の供給は、腫瘍を含めた全ての生体組織が成長するために必須であり、腫瘍血管の形成を抑制することで癌の治療を目指すというのは合理的な概念である。そのため、腫瘍に対する血管形成抑制剤がこれまでに際だった成果を上げていない理由を明らかにすることは、効果的な癌治療薬の開発を目指すためには重要な課題である。本研究によって発見された「血管移動」による栄養路の獲得と、それを制御する「血管制御ミエロイド」は、癌治療薬の新たな標的となると期待できる。
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