Alcohol metabolism gene polymorphism and alcohol consumption affect serum magnesium concentration in head and neck cancer cases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06774
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ARIIZUMI Yosuke 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (30444110)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 低マグネシウム血症 / 飲酒 / 遺伝子多型 / 頭頸部癌 / 腎機能障害 / シスプラチン

Outline of Final Research Achievements

A study was conducted to measure the polymorphism of alcohol metabolism - related genes and the influence of alcohol consumption on hypomagnesemia in head and neck cancer patients receiving cisplatin administration. Alcohol metabolism is affected by the ALDH2 / ADH1B gene, so magnesium is considered to be affected as well. About 20 cases of genetic tests are done at the time of the report, but we can not draw a conclusion because there are only a few cases of hypomagnesemia. We plan to add cases in the future.

Free Research Field

頭頸部癌