2018 Fiscal Year Final Research Report

Analysis of neural functional recovery mechanism immediately after bone marrow stem cell transplantation for spinal cord injury

Research Project

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Project/Area Number	16K10830
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Sapporo Medical University
Principal Investigator	Oshigiri Tsutomu 札幌医科大学, 医学部, 助教 (70754612)
Co-Investigator(Kenkyū-buntansha)	本望修札幌医科大学, 医学部, 教授 (90285007) 山下敏彦札幌医科大学, 医学部, 教授 (70244366) 佐々木祐典札幌医科大学, 医学部, 講師 (20538136) 森田智慶札幌医科大学, 医学部, 研究員 (60723343)
Project Period (FY)	2016-10-21 – 2019-03-31
Keywords	脊髄損傷 / 再生 / 骨髄間葉系幹細胞 / 静脈内投与 / 急性期 / メカニズム / 脳 / 遺伝子
Outline of Final Research Achievements	While functional recovery from transvenous administration of bone marrow mesenchymal stem cells (MSCs) to spinal cord injury (SCI) models has been reported, the role of the brain in spinal cord injury has attracted attention. In this study, MSCs were intravenously administered to acute-phase SCI rats, and 15 genes related to recovery of motor function were extracted from comprehensive gene expression analysis by brain microarray. This suggests that intravenous administration of MSC has neuroprotective and regenerating effects on the brain and is involved in recovery of motor function.
Free Research Field	脊髄再生
Academic Significance and Societal Importance of the Research Achievements	脊髄損傷患者に対する骨髄間葉系幹細胞の静脈内投与による再生医療の治療メカニズムの一つとして、脳における神経保護作用や神経再生作用が運動機能回復に関与していることがわかり、静脈内投与による脊髄局所だけでなく全身投与によって脳への作用が重要であることが分かった。今後脊髄損傷の再生医療のアプローチとして損傷局所だけでなく、中枢神経全体への治療介入の重要性が示唆された。