Molecular mechanism of IL-17 production in anti-fungal immunity

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15271
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Chiba University
• Principal Investigator: SAIJO Shinobu 千葉大学, 真菌医学研究センター, 准教授 (60396877)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 感染免疫 / サイトカイン / 真菌感染

Outline of Final Research Achievements

Fungi are ubiquitous in environments and host immune systems are constantly engaged with these eukaryotic pathogens. We have reported taht C-type lectin receptors (CLRs) that expressed in myeloid cells play a central role in host defenses against fungal infections by coordinating immune systems. Cytokine production is one of the most characteristic and crucial responses in anti-fungal immunity led by ligand ligation of CLRs. However, in vivo mechanisms of this process has not been fully explained . In this study, we describe the molecular mechanisms of cytokine production in anti-fungal activities by the host immune systems.

Free Research Field

細菌学（含真菌学）