The mechanisms of immune tolerance induced by Ultraviolet B-expanded regulatory T cells in the skin.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15376
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Nagoya City University
• Principal Investigator: Odanaka Mizuyu 名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
• Co-Investigator(Kenkyū-buntansha): 今井 優樹 名古屋市立大学, 大学院医学研究科, 講師 (30440936) ; 山崎 小百合 名古屋市立大学, 大学院医学研究科, 教授 (70567255)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 紫外線 / 制御性T細胞 / 樹状細胞

Outline of Final Research Achievements

Ultraviolet B (UVB) irradiation is known to induce immune tolerance. In this study, we investigated the roles of dendritic cells (DCs) subsets for UVB-mediated immune tolerance. We found that Langerin negative DCs but not LCs or Langerin positive dermal DCs are required for regulatory T cells (Tregs) expansion in UVB-exposed skin. Upon UVB exposure, CD11b-type Langerin negative DCs upregulated the expression of several tolerogenic genes related to Tregs function and proliferation. These results indicate that CD11b-type Langerin negative DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

Free Research Field

免疫学