Searching for natural resources with DNA damage inhibitory activity by comet assay

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K18903
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines
• Research Institution: Showa Pharmaceutical University
• Principal Investigator: KURIMOTO Shin-ichiro 昭和薬科大学, 薬学部, 特任助教 (70735018)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: コメットアッセイ / 天然資源 / DNA損傷

Outline of Final Research Achievements

DNA damage and its accumulation are related to lifestyle-related disorders such as cancer so that materials possessing DNA damage inhibitory activity may be efficient to protect lifestyle-related disorders. The purpose of our study is to provide effective seeds for preventing lifestyle-related disorders. We screened the extracts of natural resources by comet assay to find several resources with the DNA damage inhibitory activity. Furthermore, forty-three compounds containing thirteen new compounds were isolated from ten samples. Their structures were elucidated by the analyses of spectral data. UV-induced DNA damage inhibitory activity of isolates was evaluated by comet assay. As a result, four compounds showed the activity.

Free Research Field

天然物化学

Academic Significance and Societal Importance of the Research Achievements

本研究により見いだしたDNA損傷抑制作用を有する天然資源および含有成分は、今後研究を進めることで、生活習慣病予防に有効な機能性食品、サプリメント、化学予防薬としての応用が期待でき、健康寿命の延伸によるQOLの向上に貢献できると考えている。