Investigation of pathogenesis of infant hypothermia-the association between undernutrition during gestation and thermogenesis-

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19271
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Nagoya University
• Principal Investigator: HAYASHI Yumi 名古屋大学, 医学系研究科(保健), 講師 (30632707)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 胎生期低栄養 / メタボロミクス

Outline of Final Research Achievements

In this study, we attempted to develop metabolome analysis techniques and create a model mouse of hypothermia to observe body temperature, activity and energy metabolism in infant exposed to undernutrition during gestation.　Metabolome analysis methods in liver, muscle and brain were developed using GC/MS/MS and probe electrospray ionization/tandem mass spectrometry (PESI/MS/MS). We tried to create a model mouse of hypothermia induced by food restriction. Mice exposed to food restriction for 10 days or more did not give birth. In 5 days restriction, mice could give birth, but body temperature of the offspring in weaning period was almost same in control group. Therefore, we continue to consider creation of a model mouse of hypothermia.

Free Research Field

衛生学