2017 Fiscal Year Final Research Report
Analysis of the effect of neuregulin 1 excess signaling on the development of GABA neuron in the critical period
| Project/Area Number |
16K19780
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Research Collaborator |
YAMASHITA Yasunori
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | neuregulin / ASD / microglia |
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| Outline of Final Research Achievements |
An abnormality in the neurodevelopment period has been pointed out in the onset of mental illness, but it is unknown in detail. From the findings we observed that the neuregulin 1 (NRG1) is expressed in microglia and the microglia-derived NRG1 is increased in the mouse model of autism spectrum disorder (ASD), we assumed that excessive NRG1 signal might affect the subsequent ASD symptoms. Since the importance of inhibitory neural circuits is reported in the cognitive function and the induction of the critical period, we investigated the influence of excessive NRG1 signal on the development of inhibitory neurons on social interaction and cognitive function.
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| Free Research Field |
精神神経科学
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