The Impact of the correlation between thrombospondin-1 and immune checkpoint

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19898
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: NAKAO Toshihiro 徳島大学, 大学院医歯薬学研究部(医学系), 徳島大学特別研究員 (60531754)
• Research Collaborator: YOSHIKAWA Kozo 徳島大学, 病院, 講師 (80448331) ; HIGASHIJIMA Jun 徳島大学, 病院, 助教 (30467815)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 胃癌 / 免役チェックポイント / THBS-1 / 発癌

Outline of Final Research Achievements

The aim of this study was to investigate the impact of correlation between TSP-1 and immune-checkpoint and clarify the role of TSP1 in gastric carcinogenesis. TSP-1 and PD-1 was a significant prognostic factor. Furthermore TSP1 was correlated with TGFβ　expression.The expression of TSP1 was high in the mucosal atrophy group and tended to be high in the Helicobacter pylori (H.pylori) (+) and multiple cancer groups. The levels of CD36, STAT3 and TGFβR2 mRNA were significantly higher in the TSP1 high group. TSP1 signaling pathway was induced in multiple cancer or atrophy (+) or H.pylori (+) compared tocases with single cancer, atrophy (-) and H.pylori (-). Expression of proteins involved in the TSP1 signaling pathway in non-cancer tissues with multiple gastric cancers were higher than that with single gastric cancer.

Free Research Field

医歯薬学