Identification of bone marrow-derived involved in pancreatic cancer progression and establishment of a new therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19937
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: Iwamoto Chika 九州大学, 医学研究院, 特任助教 (10752842)
• Research Collaborator: OHUCHIDA Kenoki ; OKUMURA Takashi ; ENDO Sho ; KOIKAWA Kazuhiro ; TAKESUE Shin
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 膵癌

Outline of Final Research Achievements

In breast cancer, a subset of stromal cells was descended from bone marrow (BM)-derived cells. While BM-derived cells seem to be involved in remodeling of microenvironment and tumor progression in pancreatic cancer, this mechanism remains unknown. We aimed to investigate an association between pancreatic cancer progression and BM-derived cells.
The engraftment of BM-derived GFP+ cells was detected in recipients’ peripheral blood, BM, pancreas, liver, and ascites. In recipients’ pancreas, GFP+ cells were accumulated around ADM/PanIN and at invasive front. Invasive capability of cancer cells co-cultured with BM-derived cells significantly increased compared to the control. The present data also suggest that BM-derived cells is involved in infiltration of cancer cells.

Free Research Field

分子腫瘍学