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2017 Fiscal Year Final Research Report

Epigenetic bases for HSCs aging and development of hematopoietic disorder

Research Project

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Project/Area Number 16K20959
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Medical genome science
Research InstitutionChiba University

Principal Investigator

Oshima Motohiko  千葉大学, 大学院医学研究院, 助教 (70506287)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywords老化造血幹細胞
Outline of Final Research Achievements

We found that PRC2 target genes were de-repressed in aged hematopoietic stem cells (HSCs) compared with young HSCs. We performed ChIP-seq and found that H3k27me3 levels of PRC2 target genes around TSS were significantly decreased in aged HSCs. chronic inflammation stress, which is known to be one of aging stress, caused significantly decreased H3K27me3 levels and acquired aging gene expression profile. In aged HSCs, we found that Ezh2 S21 phosphorylation, which is related to dysfunction of PRC2 complex, was significantly increased.

Free Research Field

分子生物学

URL: 

Published: 2019-03-29  

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