Study on the development of lncRNA biomarkers in radiation therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20972
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics; Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: Miyagawa Ryu 東京大学, 医学部附属病院, 特任助教 (20721939)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: がん / 放射線 / 放射線治療 / バイオマーカー / 非コードRNA

Outline of Final Research Achievements

The purpose of this study is to elucidate the new mechanisms of radiation-responsive non-coding RNA (ncRNA) for the establishment of a new biomarker in radiation therapy. I used X-ray-irradiated cancer-derived cultured cells. First, I identified the expressoion change of some ncRNAs by qPCR. Concurrently, I also identified the localization change of some ncRNAs and some proteins by FISH and IF methods. But I was not able to identify the interaction of those ncRNAs with proteins.

Free Research Field

分子生物学、細胞生物学、放射線生物学