Reduction of HbA1c levels by fucoxanthin on UCP1 gene polymorphism

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21251
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits; Metabolomics
• Research Institution: Sapporo Medical University
• Principal Investigator: Mikami Nana 札幌医科大学, 医学部, 助教 (80700278)
• Research Collaborator: Kokai Yasuo 札幌医科大学, 医学部・フロンティア医学研究所, 教授 (20178239) ; Sohma Hitoshi 札幌医科大学, 医療人育成センター・教育開発研究部門, 教授 (70226702)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: UCP1遺伝子多型 / フコキサンチン / ヘモグロビンA1c

Outline of Final Research Achievements

In our previous study, we showed 8-week fucoxanthin administration reduced HbA1c levels of　healthy people especially in G/G allele carriers of UCP1 -3826A/G polymorphism. Because the carriers are known to be high risk population for onset of obesity and type 2 diabetes, we verified the Fx effects targeting on 120 people with prediabetes in this study. As a result, no significant differences were detected on HbA1c levels between UCP1 genotypes. These results suggest that Fx effects on UCP1 polymorphism may be associated with HbA1c distribution of target population (healthy or prediabetic) and outdoor temperature of trial period.

Free Research Field

食品機能性