• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2019 Fiscal Year Final Research Report

Comprehensive analysis of gut microbiome and epigenetic changes in esophageal cancer.

Research Project

  • PDF
Project/Area Number 17H04273
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKumamoto University

Principal Investigator

Baba Yoshifumi  熊本大学, 病院, 非常勤診療医師 (20599708)

Co-Investigator(Kenkyū-buntansha) 美馬 浩介  熊本大学, 病院, 非常勤診療医師 (00546559)
澤 智裕  熊本大学, 大学院生命科学研究部(医), 教授 (30284756)
吉田 直矢  熊本大学, 病院, 特任准教授 (60467983)
Project Period (FY) 2017-04-01 – 2020-03-31
Keywords腸内細菌叢 / LINE-1 / 食道癌 / 腫瘍免疫 / Fusobacterium
Outline of Final Research Achievements

Fusobacterium nucleatum (F. nucleatum), which primarily inhabits the oral cavity, causes periodontal disease. F. nucleatum influences the development and progression of esophageal cancer. First, we showed that F. nucleatum tumors had lower LINE-1 methylation level (global DNA methylation). Second, we could demonstrate that LINE-1 hypomethylation was associated with LINE-1 copy number in esophageal cancers. Third, we found that tumor LINE-1 hypomethylation level was associated with a diminished peritumoral lymphocytic reaction.

Free Research Field

外科腫瘍学、腫瘍免疫学

Academic Significance and Societal Importance of the Research Achievements

腸内細菌叢microbiomeは薬剤などにより後天的に変化させうるものであり、疾患治療のターゲットとしてもきわめて有望である。よって、“Fusobacteriumという口腔内に存在する菌が、食道癌のメチル化や腫瘍免疫に関与する”という今回得られた結果は臨床応用に直結する可能性があり、創薬へ向けた橋渡し研究として極めて意義深いものである。

URL: 

Published: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi