Establishment of a novel periodontal tissue regeneration therapy through acquisition of periodontal ligament stem cell induction factor

2018 Fiscal Year Final Research Report

• Project/Area Number: 17H06953
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontology
• Research Institution: Kyushu University
• Principal Investigator: Mitarai Hiromi 九州大学, 大学病院, 助教 (60801660)
• Project Period (FY): 2017-08-25 – 2019-03-31
• Keywords: 歯根膜幹細胞 / MEST / 培養上清

Outline of Final Research Achievements

In this study, we found that the human periodontal ligament cell line transfected with MEST gene acquired stem cell characteristics. In addition, the MEST-overexpressed cell supernatant was found to promote the migration ability of human periodontal ligament cells. Furthermore, we identified a factor X, which related to acquisition of stem cell characteristic by MEST. These results suggested that MEST was involved in the acquisition of human periodontal ligament stem cells and was a key factor for periodontal tissue regeneration therapy.

Free Research Field

歯周組織再生

Academic Significance and Societal Importance of the Research Achievements

我々は、本研究で得られた知見により、MESTによって獲得した歯根膜幹細胞を用いた新たな歯周組織再生治療法の開発に繋がるのではないかと考えている。