2020 Fiscal Year Final Research Report

A prospective study about association between 25-hydroxyvitamin D and cognitive decline and development of lifestyle-related diseases.

Research Project

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Project/Area Number	17K09121
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Epidemiology and preventive medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	ozaki etsuko 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00438219)
Co-Investigator(Kenkyū-buntansha)	渡辺能行京都先端科学大学, 健康医療学部, 教授 (00191809) 渡邉功京都府立医科大学, 医学(系)研究科(研究院), 助教 (10636525) 松井大輔京都府立医科大学, 医学(系)研究科(研究院), 助教 (20613566) 小山晃英京都府立医科大学, 医学(系)研究科(研究院), 助教 (40711362) 栗山長門京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60405264) 上原里程京都府立医科大学, 医学(系)研究科(研究院), 教授 (90276999)
Project Period (FY)	2017-04-01 – 2021-03-31
Keywords	25（OH)D / 認知機能 / ビタミンD
Outline of Final Research Achievements	Serum 25(OH) D concentrations differed between males and females and between seasons, similar to the previous direction. In relation to the frequency of dietary intake, it was confirmed that fish intake had a preventive effect on the reduction of serum 25(OH) D concentrations in both men and women, even after adjusting for season and outdoor time, but this was not the case for mushrooms, which have been reported previously. The association between serum 25(OH)D concentration and cognitive function assessment was not found to be related to the Mini-Mental State Examination, which is a screening test for cognitive function, but it was found to be an independent factor in Word Fluency Test and Symbol Digit Modalities Test, even after adjusting for sex, age, BMI, abdominal circumference, presence of diabetes, presence of hypertension, presence of dyslipidemia, presence of stable drugs/sleeping pills, alcohol consumption, smoking, and education.
Free Research Field	栄養疫学
Academic Significance and Societal Importance of the Research Achievements	ビタミンDは骨粗鬆症、がん、糖尿病、動脈硬化、自己免疫疾患といった現代社会の主要疾患と深い関係があり、その指標となるのは血清25（OH）D濃度であるといわれている。日本人の血清25（ＯＨ）Ｄ濃度は以前から言われているとおり低値を示していたものが多かった。今後、縦断的解析を進めて最適な値を確立するためには今回の値を示せたことは学術的に意義があるものと考える。また、血清25（OH）D濃度は認知機能、特に語想起課題や情報処理能力の独立した因子である可能性を示せたことは、高齢化社会に向けての社会的意義があるものだと考える。