Elucidation of regulatory mechanism for colonic motility

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10648
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: Shibata Chikashi 東北医科薬科大学, 医学部, 教授 (30270804)
• Co-Investigator(Kenkyū-buntansha): 小川 仁 東北医科薬科大学, 医学部, 准教授 (00312570) ; 坂井 貴文 埼玉大学, 理工学研究科, 教授 (40235114) ; 坂田 一郎 埼玉大学, 理工学研究科, 准教授 (80610831)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 大腸運動

Outline of Final Research Achievements

Elucidation of regulatory mechanism for colonic motility is importnat, because abnormal colonic motility is associated with diseases impairing patients’ quality of life. We established system to measure gastric and colonic motility by means of strain gauge force transducers and watch behavior simultaneously for 24 hours in Suncus murinus. Giant migrating contractions always accompanied with defecations, and feeding and drinking were frequently observed immediately before and after defecations. Intravenous administration of motilin, a gastrointestinal hormone having stimulatory effects on gastric motility, had no effects on colonic motility. While yohimbine, an antagonist for adrenergic receptors, stimulated giant migrating contractions with defecations. These results indicate that regulatory mechanism for colonic motility in Suncus murinus is similar to humans and dogs and Suncus murinus is useful for translational research.

Free Research Field

消化器外科

Academic Significance and Societal Importance of the Research Achievements

スンクスで認められた巨大伝搬性収縮波はヒトやイヌで排便時に起こることはすでに認められており、また、食事摂取直後の排便はヒトやイヌで報告されている胃結腸反射がスンクスでも存在する可能性を示している。さらに、ヨヒンビンの巨大伝搬性収縮波と排便の誘発効果はイヌで知られている。このようにスンクスの大腸運動メカニズムはヒトやイヌに類似していることから、ヒトへのトランスレーショナル研究に有用であると考えられる。