2019 Fiscal Year Final Research Report
Effects of drugs (amino acid, Mg, acetaminofen) on the shivering thresholds in rabbits.
| Project/Area Number |
17K11045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 体温 / 体温調節機構 / シバリング / アミノ酸 / マグネシウム / 閾値温度 |
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| Outline of Final Research Achievements |
We often observe the intraoperative hypothermia, which can induce patient’s shivering. Shivering might be the cause of patient’s discomfort and hypoxemia. We experienced the effect of drugs (amino acid, Mg) on the shivering threshold in rabbits. We observed the Amino acid, and Mg have a tendency of decreasing the shivering threshold. These results can be applied to the safe temperature management of patients perioperatively.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
シバリングが発生すると、患者の生命予後にも重大な危険性が増加する可能性がある。周術期に投与される機会の多い薬剤と体温調節性シバリングとの関係を研究調査し、手術期（とくに術後）の合併症として出現するシバリングの発生を防ぎ得ることが判明し、臨床応用への展開が大いに期待される。
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