2019 Fiscal Year Final Research Report

Prognostic analysis of ADC level in MRI for localized bladder carcinoma patients.

Research Project

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Project/Area Number	17K11153
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Urology
Research Institution	Nagoya City University
Principal Investigator	NAGATA DAISUKE 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (20336689)
Co-Investigator(Kenkyū-buntansha)	安井孝周名古屋市立大学, 医薬学総合研究院(医学), 教授 (40326153) 河合憲康名古屋市立大学, 医薬学総合研究院(医学), 准教授 (20254279) 安藤亮介名古屋市立大学, 医薬学総合研究院(医学), 教授 (30381867) 内木拓名古屋市立大学, 医薬学総合研究院(医学), 講師 (50551272) 飯田啓太郎名古屋市立大学, 医薬学総合研究院(医学), 臨床研究医 (30713945) 惠谷俊紀名古屋市立大学, 医薬学総合研究院(医学), 助教 (30600754) 中川基生名古屋市立大学, 医薬学総合研究院(医学), 講師 (60590982) 内木綾名古屋市立大学, 医薬学総合研究院(医学), 准教授 (20509236)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	膀胱癌 / 拡散強調画像
Outline of Final Research Achievements	Recent report described that apparent diffusion coefficient (ADC) levels in magnetic resonance imaging (MRI) correlate the malignant levels in bladder carcinoma. However, those could not analyze including the prognosis. Therefore, the purpose of this study is to investigate the prognostic value of ADC levels in localized bladder cancer patient. From 2007 to 2012, total of eligible 141 patients who were performed TURB were enrolled.The median age was 71 years old. The T stage was 38 cases in pTa, 62 cases in pT1, and 41 cases in T2 or more, with 35 cases in low grade and 116 cases in high grade. The more T stage was worsened, ADC levels significantly decreased. Particular in pT1 cases, cases in low level of ADC group were significantly poor PFS compared with in high level group. Furthermore, multivariate analysis revealed that ADC levels was independent prognostic factor in pT1 patients. In pT1 bladder carcinoma patients, the ADC levels could be good prognostic biomarker.
Free Research Field	泌尿器悪性腫瘍
Academic Significance and Societal Importance of the Research Achievements	本検討において、ADC値はT1膀胱癌の進展を予測する因子となり得た。癌におけるADC値は、組織の細胞密度だけでなく、低酸素や炎症などの周囲環境も反映されるため、病理組織学的因子とは異なった予測因子となると考えられた。ADC値は、T1膀胱癌において病理組織学的因子とは異なる、進展を予測する因子である可能性が示唆された。