Functional analysis of soluble B7-H3

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K11169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Tokyo Metropolitan Tama Medical Center (Department of Clinical Research)
• Principal Investigator: AZUMA TAKESHI 東京都立多摩総合医療センター(臨床研究・教育研修センター(臨床研究部)), 泌尿器科, 部長 (50719854)
• Co-Investigator(Kenkyū-buntansha): 久米 春喜 東京大学, 医学部附属病院, 教授 (10272577) ; 佐藤 雄二郎 東京都立多摩総合医療センター(臨床研究・教育研修センター(臨床研究部)), 泌尿器科, 医員 (40770871)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: B7-Ｈ３ / 膀胱癌 / イムノチェックポイント分子 / 腫瘍免疫

Outline of Final Research Achievements

We detected high levels of sB7-H3 in the sera of 47% of patients with NMIBC versus only 8% in healthy donors. The increase of sB7-H3 was significantly associated with poor RFS and PFS. Multivariate analysis showed that elevated sB7-H3 was an independent prognostic factor of RFS and PFS. According to the European Organization for Research and Treatment of Cancer (EORTC), in intermediate-low and intermediate-high risk groups, the presence of sB7-H3 significantly determined the rate of recurrence and progression.

Free Research Field

泌尿器科　腫瘍免疫

Academic Significance and Societal Importance of the Research Achievements

血清中の可溶型B7-H3濃度は有効な血清腫瘍マーカーになりうることが示唆された。
日常診療において、表在性膀胱癌の再発と進行の予測の精度が改善された。