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2021 Fiscal Year Final Research Report

Elucidation of pathological pain via nociceptors and its application to pain relief

Research Project

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Project/Area Number 18H02345
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionTottori University

Principal Investigator

OHTA Toshio  鳥取大学, 農学部, 教授 (20176895)

Co-Investigator(Kenkyū-buntansha) 高橋 賢次  鳥取大学, 農学部, 准教授 (00400143)
稲波 修  北海道大学, 獣医学研究院, 教授 (10193559)
今川 敏明  北海道大学, 理学研究院, 特任准教授 (20142177)
Project Period (FY) 2018-04-01 – 2022-03-31
Keywords疼痛
Outline of Final Research Achievements

This study clarified that the activation of TRPA1 expressed in sensory neurons is regulated by low-threshold voltage-gated Ca channels and that TRPA1 activity by oxidative stress substances produced during inflammation is modulated by endogenous sulfur compounds. Studies on species differences in TRP channel function revealed the importance of TRPA1 channels as a site of action in bird repellents and differences between mammals and birds in TRPV1 antagonists. A search for compounds that inhibit TRPV1 function revealed that some vanilloids showed inhibitory action on TRPV1.

Free Research Field

細胞薬理学

Academic Significance and Societal Importance of the Research Achievements

本研究では、各種チャネル遺伝子発現細胞、実験動物より単離した知覚神経細胞及び動物個体を用いて行い、作用の分子メカニズムについて遺伝子レベル、細胞レベル及び個体レベルで検討した。その結果、本研究においてTRPチャネルの新しい機能の解明、化学物質の毒性発現機構、忌避作用におけるTRPチャネルの病態生理学的意義を明らかにすることが出来た。本研究の成果は、新規鎮痛薬や新しい疼痛緩和法の開発並びに痛み関連の病態解明に向けた基礎的知見を提供すると考えられる。

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Published: 2023-01-30  

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