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2021 Fiscal Year Final Research Report

Nerve-dependent tissue repair mechanism after damage

Research Project

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Project/Area Number 18H02524
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionNagoya University

Principal Investigator

Sumiko Kiryu-Seo (瀬尾寿美子)  名古屋大学, 医学系研究科, 准教授 (70311529)

Project Period (FY) 2018-04-01 – 2022-03-31
Keywords組織修復 / 神経再生 / ペプチド / プロテアーゼ / 神経制御
Outline of Final Research Achievements

Damage-induced neuronal endopeptidase (DINE) is a unique molecule which responds to various kinds of neuronal injuries both in CNS and PNS. Tissue injury such as skin injury is accompanied by the damage of sensory nerves, which abundantly distributed in skin. After tissue damage, injury-induced DINE might regulate the microenvironment through its cleaved peptide to promote tissue repair in a nerve-dependent manner.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

神経精神疾患や生活習慣病など多くの疾患研究から脳・神経と臓器とが密接に関係することが近年次第に明らかになりつつあるが、組織・臓器の修復がいかに神経によって制御されるのかそのメカニズムは不明である。神経損傷応答性を利用したDINEによる神経依存性創傷治癒機構は組織修復時に問題となる瘢痕形成を回避するための新たなメカニズムと考えられ、この分子を標的とした創薬や再生医療への発展が期待される。

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Published: 2023-01-30  

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