2021 Fiscal Year Final Research Report
Oncolytic virus targeting tumor associated mesenchymal stem cells
| Project/Area Number |
18H02691
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
粕谷 英樹 名古屋大学, 医学系研究科, 教授 (00402636)
直江 吉則 名古屋大学, 医学系研究科, 特任准教授 (50392048)
一ノ瀬 亨 名古屋大学, 医学系研究科, 研究員 (60778091)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | 腫瘍溶解性ウイルス |
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| Outline of Final Research Achievements |
One of the mechanisms for immune suppression in pancreatic tumors is the recruitment of mesenchymal stem cells (MSC), which turn into tumor-associated fibroblasts. C-REV, our oncolytic virus, has been shown to dramatically change the tumor microenvironment. Here, we examined whether C-REV has the ability to kill MSC in the tumor tissue. A naturally mutated attenuated HSV1, C-REV cannot replicate inside the healthy normal cells. However, we found that C-REV can infect and replicate in the MSC. Furthermore, C-REV treatment on the MSC-injected pancreatic tumors showed decreased numbers of MSC in the mouse model.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で派生的に検証し報告したSTING経路と腫瘍溶解性ウイルスの知見は、新規治療法の提案につながった。2’3’-cGAMPは天然のSTINGアゴニストであるが、様々なSTING アゴニストが世界中で開発競争を繰り広げている。腫瘍溶解性ウイルスとの併用療法は報告されておらず、今後臨床研究されていく可能性がある。
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