Establishment of clinical significance of serum hepatic lipase assay and its clinical application

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07484
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Toho University (2019-2020); Kanazawa Medical University (2018)
• Principal Investigator: Kobayashi Junji 東邦大学, 医学部, 客員教授 (60302577)
• Co-Investigator(Kenkyū-buntansha): 中嶋 克行 女子栄養大学, 付置研究所, 客員教授 (10444051) ; 多田 隼人 金沢大学, 附属病院, 助教 (90623653)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 肝性リパーゼ / SYNTAXスコア / 冠動脈疾患

Outline of Final Research Achievements

Hepatic lipase (HL) is a lipid metabolizing enzyme that hydrolyzes TG in remnants and HDL. It is not clear whether it is pro- or anti-atherosclerotic. We investigated the relationship between HL protein levels and the SYNTAX score, which quantitatively assesses the severity of coronary artery disease. The subjects were 100 patients (age 70.7±11.5 years, LDL-C 101±32 mg/dl, 87 males) who underwent coronary angiography, and HL protein levels were measured by a method developed by us.　The correlation coefficients between SYNTAX score and serum HL and post-heparin plasma HL protein levels were r = 0.214 (ns) and r = -0.178 (ns), respectively. These results indicate that there is no significant correlation between hepatic lipase protein level and SYNTAX score.

Free Research Field

臨床検査医学

Academic Significance and Societal Importance of the Research Achievements

今回の検討からは冠動脈疾患重症度を定量的に評価するSYNTAXスコアと肝性リパーゼとの明らかな相関はみられなかった。一方で対象が100例と少なかったことも影響すると考える。肝性リパーゼを簡便に測定できる方法が確立しているので、今後は多数の対象で検討し、男女差、糖尿病の有無、腎臓病の有無などで層別化し検討を進めていく意義のあるテーマと考えている。