Consideration of effectiveness of intra-abdominal hyperthermia chemotherapy devised from abscopal effect

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08592
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Mie University
• Principal Investigator: Miki Chikao 三重大学, 医学系研究科, 客員教授 (50242962)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学系研究科, 教授 (00422824) ; 奥川 喜永 三重大学, 医学部附属病院, 講師 (30555545) ; 藤川 裕之 三重大学, 医学部附属病院, 助教 (40616091) ; 安田 裕美 三重大学, 医学部附属病院, 助教 (60586767) ; 楠 正人 三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 胃癌 / アブスコパル効果 / 腹膜播種

Outline of Final Research Achievements

It was difficult to elucidate for abscopal effect with intra-abdominal hyperthermia chemotherapy, because we could not make the mouse model with gastric cancer peritoneal metastases.
High L1CAM expression was significantly associated with peritoneal metastasis. Gastric cancer tissue PD-L1 expression was significantly higher in the GC patients with and peritoneal metastasis. Additionally, CLR size correlated with patient nutritional status and prognosis and may be helpful in identifying high-risk populations of GC patients.

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果を用いることで、胃癌患者における新たな予後マーカーの可能性が示唆された。腫瘍側と宿主側の両方向性にAbscopal効果の機序解明とAbscopal効果予測マーカーの確立につながると考える。