2020 Fiscal Year Final Research Report

Elucidation of the expression and regulation mechanisms of Lubricin aiming at the development of a new treatment for osteoarthritis of the jaw

Research Project

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Project/Area Number	18K09769
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	The University of Tokushima
Principal Investigator	KURIO Naito 徳島大学, 病院, 講師 (80622141)
Co-Investigator(Kenkyū-buntansha)	福田直志徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (10804156) 宮本洋二徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (20200214) 中川貴之広島大学, 病院(歯), 助教 (30456230) 高丸菜都美徳島大学, 病院, 講師 (40513031) 大江剛徳島大学, 大学院医歯薬学研究部(歯学域), 徳島大学専門研究員 (60432762) 真野隆充徳島大学, 大学院医歯薬学研究部(歯学域), 徳島大学専門研究員 (80325125)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	変形性顎関節症 / PRG4 / TGFβ
Outline of Final Research Achievements	TMJ-OA is characterized by the destruction of the osteochondral constituents of the temporomandibular joint, which reduces the patient's QOL due to arthralgia and trismus. Once the disease develops, a fundamental treatment method for repairing the deformed joint has not been established, and development of a new treatment method is desired, but the pathological condition is often unknown, and elucidation of the pathogenic mechanism is urgently needed. Lubricin plays an important role in the protection of articular cartilage, but there are many unclear points regarding its expression regulation mechanism. In this study, we analyzed the role of TGF-signal in the production of Lubricin in the temporomandibular joint and the mechanism of molecular regulation. This study is considered to be a basic study for establishing preventive methods and new treatment methods for TMJ-OA.
Free Research Field	口腔外科学
Academic Significance and Societal Importance of the Research Achievements	変形性顎関節症(TMJ-OA)は顎関節を構成する骨軟骨の破壊を特徴とし、関節痛や開口障害により患者のQOLを低下させる。一旦発症した場合、変形した関節を修復させる根本的治療法は確立されておらず新規治療法の開発が望まれるが病態が不明であることが多く発症機序の解明が急務である。Lubricinは関節軟骨の保護に重要な役割を持つが、その発現調節機構に関しては不明な点が多い。本研究では顎関節のLubricin産生におけるTGF-シグナルの役割と分子調節機構の解析を行った。本研究はTMJ-OAの予防法や新たな治療法の確立のための基礎研究となると考えられる。