A development of MEMS autonomic neural recording device and two-photon neural imaging

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K19950
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Okayama University
• Principal Investigator: KAMIYA ATSUNORI 岡山大学, 医歯薬学総合研究科, 教授 (30324370)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Keywords: 自律神経

Outline of Final Research Achievements

The autonomic nerves are cables, that connect the brain with organs. They transmit command signals to the organ and regulate its function. In the present study, we have developed a new method to record individual nerve fiber activities between organs that are difficult to be examined by existing methods, and also a new one to microscopic image the neural activities (seeing). In addition, by using these methods, we have recorded sympathetic nerve activity that innervates the breast cancer tissue.

Free Research Field

自律神経

Academic Significance and Societal Importance of the Research Achievements

自律神経系は、全身の臓器に分布し、身体各所の生体情報を感知して脳に送り（求心路）、各臓器の機能を調節します（遠心路）。自律神経系は、健康時においては、生体恒常性や生命を維持する役割を担いますので、一方、病態とも深く関わっています。従って、本研究で開発した、自律神経線維の活動を解析する方法は、健康時における、各臓器に分布する自律神経の働きを理解したり、がんを含む様々な病気の仕組み（病態生理）を解明する上においても、役に立つように期待されます。