2011 Fiscal Year Final Research Report
Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinases
| Project/Area Number |
19109004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Satsuki 慶應義塾大学, 医学部, 講師 (80365428)
IKEDA Eiji 山口大学, 医学部, 教授 (30232177)
SHIMODA Masayuki 慶應義塾大学, 医学部, 助教 (70383734)
FUJII Yutaka 福井大学, 医学部, 教授 (80211522)
KIMURA Tokuhiro 慶應義塾大学, 医学部, 助教 (40445200)
SASAKI Aya 慶應義塾大学, 医学部, 助教 (60343381)
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| Co-Investigator(Renkei-kenkyūsha) |
KIRAN Chada ニュージャージ医科歯科大学, 医学部, 教授
JEANINE D' armiento コロンビア大学, 医学部, 准教授
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| Project Period (FY) |
2007 – 2011
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| Keywords | MMP / ADAM / ノックアウトマウス / 浸潤 / 転移 / 創傷治癒 / 変形性関節症 / ヒアルロン酸 |
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| Research Abstract |
We searched for interacting molecules for members of the MMP (matrix metalloproteinase) and the ADAM (a disintegrin and metalloproteinase) gene families, and investigated roles of these metalloproteinases in metabolism of tissue microenvironmental factors in cancers and non-neoplastic diseases with an aim of developing novel diagnostic and/or therapeutic tools. Our studies provided progresses in purification of several proMMPs, roles of MMPs in skin wound healing, implications of ADAM28 in cancer cell proliferation and metastasis, development of a measuring method for ADAM28, and roles of ADAMTS4 and ADAM12 in destruction and repair of osteoarthritic cartilage.
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