2011 Fiscal Year Final Research Report
Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
| Project/Area Number |
19109008
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TAKIGAWA Masaharu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
HATTORI Takako 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)
NISHIDA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
AOYAMA Eriko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
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| Project Period (FY) |
2007 – 2011
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| Keywords | CCNファミリー / シグナルコンダクター / 結合分子 / 遺伝子発現 |
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| Research Abstract |
We have established a novel concept that CCN family proteins should be considered a newly classified signaling molecules that comprehensively regulate extracellular signals, and thus should be entitled "Signal Conductors." Moreover, we have accumulated basic data for application of CCN proteins toward harmonized regenerative medicine and for therapeutics of diseases with their abnormal upregulation, leading to their medical applications.
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[Journal Article] CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.2009
Author(s)
Maeda, A., Nishida, T., Aoyama, E., Kubota, S., Lyons, K. M., Kuboki, T., Takigawa, M.
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Journal Title
J. Biochem
Volume: 145(2)
Pages: 207-216
Peer Reviewed
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[Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan2009
Author(s)
Aoyama, E., Hattori, T., Hoshijima, M., Araki, D., Nishida, T., Kubota, S., Takigawa, M.
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Journal Title
Biochem. J.
Volume: 420
Pages: 413-420
Peer Reviewed
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[Journal Article] Clinical significance and pathogenic function of connective tissue growth factor(CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.2008
Author(s)
Shimo, T. Kubota, S., (中3名), Nishida, T., Ng, P. S., Endo, K., Takigawa, M. Sasaki, A.
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Journal Title
Anticancer Res.
Volume: 28(4C)
Pages: 2343-2348
Peer Reviewed
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