2010 Fiscal Year Final Research Report
Molecular basis of autophagy as a cellular survival strategy
| Project/Area Number |
19207015
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIMORI Tamotsu Osaka University, 大学院・生命機能研究科, 教授 (60191649)
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| Project Period (FY) |
2007 – 2010
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| Keywords | オートファゴソーム / 隔離膜 / 生存維持 / Atg16L / LC3 / 膜の起源 |
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| Research Abstract |
Eukaryotic cells maintain their life by using autophagy, an intracellular bulk degradation system in the diverse aspects. To understand autophagy as a cellular survival strategy, we achieved molecular dissection of autophagy. In results, we found that Atg16L complex anchors LC3 to the autophagic membrane structure and that LC3 is required for completion of the structure. Furthermore, formation of the structure occurs inside of the special "cradle" derived from the endoplasmic reticulum membranes.
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[Journal Article] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.(§These authors contributed equally to this work.)2009
Author(s)
Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S
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Journal Title
Proc Natl Acad Sci USA. 106
Pages: 20842-20846
Peer Reviewed
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[Journal Article] Two Beclin-1 binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.2009
Author(s)
Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda, K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T.
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Journal Title
Nature Cell Biol. 11
Pages: 385-396
Peer Reviewed
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[Journal Article] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced L-1beta production.(§These authors contributed equally to this work.)2008
Author(s)
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, shimori T, Akira S.
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Journal Title
Nature. 456
Pages: 264-268
Peer Reviewed
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[Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila.2008
Author(s)
Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S.
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Journal Title
Nat Immunol. 9
Pages: 908-916
Peer Reviewed
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