2010 Fiscal Year Final Research Report
Effects of environmental pollutants on cancer in wildlife
| Project/Area Number |
19208028
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Boundary agriculture
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUJITA Shoichi Hokkaido University, 名誉教授 (10143314)
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| Co-Investigator(Kenkyū-buntansha) |
IKENAKA Yoshinori 北海道大学, 大学院・獣医学研究科, 講師 (40543509)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIZUKA Mayumi 北海道大学, 大学院・獣医学研究科, 教授 (50332474)
SAKAMOTO Kentaro 北海道大学, 大学院・獣医学研究科, 講師 (80374627)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 環境汚染 / 野生動物 / プレデター / 化学発癌 / シトクロムP450 |
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| Research Abstract |
We investigated bioaccumulation levels of environmental chemicals, e.g., carcinogens and pro-carcinogens, in wildlife and elucidated the effects of these environmental toxic compounds. We cloned cytochrome P450 1 subfamilies, arylhydrocarbon receptors and phase II enzymes, which contribute to activation or detoxification of carcinogens and procarcinogens, from bird and mammalian species including rare wildlife, and characterized these molecules. We also reported the molecular evolution of these enzymes and regulation receptors in wildlife.
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[Presentation] The Environmental Pollution in Zambia : Current status of POPs and heavy metals pollution in wildlife and domestic animals in Zambia2010
Author(s)
Ikenaka Y, Muroya T, Nakayama S, Saentienchai A, Muzaundu K, Choongo K, John Y, Ishizuka M
Organizer
31st Annual Meeting in North America of the Society of Environmental Toxicology and Chemistry (SETAC)
Place of Presentation
Oregon Convention Center, Portland, Oregon, USA.
Year and Date
20101107-20101111
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