2009 Fiscal Year Final Research Report
Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorder
| Project/Area Number |
19300133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyorin University |
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Principal Investigator |
AKAGAWA Kimio Kyorin University, 医学部, 教授 (80129303)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Tomonori 杏林大学, 医学部, 講師 (90255399)
SUGA Kei 杏林大学, 医学部, 助教 (30306675)
MISHIMA Tatsuya 杏林大学, 医学部, 助教
KOFUJI Takefumi 杏林大学, 医学部, 助教 (40365200)
SANADA Masumi 杏林大学, 医学部, 実験助手 (70424108)
SAITOU Ayako 杏林大学, 医学部, 実験助手 (80424109)
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| Project Period (FY) |
2007 – 2009
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| Keywords | シナプス伝達 / シンタキシン1A / シンタキシン1B / ノックアウトマウス自閉性障害 / 疾患モデル動物 / シナプス機能分化 |
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| Research Abstract |
It was suggested by studying syntaxin1A (sy1A) or syntaxin1B (sy1B) gene knockout mice that sy1A and sy1B function in monoaminergic and mainly in glutamatergic fast transmission respectively. These findings overturned the usual thought that sy1a and sy1B played similar roles in synaptic function.
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