2009 Fiscal Year Final Research Report
Development of Chiral Bronsted Acid Catalysts
| Project/Area Number |
19350026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Gakushuin University |
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Principal Investigator |
AKIYAMA Takahiko Gakushuin University, 理学部, 教授 (60202553)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 不斉合成 / 有機合成化学 / 触媒 / エナンチオ選択性 / リン酸 / キラルブレンステッド酸 / 有機触媒 |
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| Research Abstract |
Asymmetric reactions by means of chiral phosphoric acid derived from (R)-BINOL as chiral Bronsted acid were investigated. Transfer hydrogenation reaction was achieved by use of a novel hydrogen donor. In order to expand the scope of the chiral phosphoric acid catalyzed reactions, intramolecular aldol reaction was studied and the corresponding cyclohexenone were obtained with excellent enantioselectivities.
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