2009 Fiscal Year Final Research Report
The mechanism for fear learning concerning NMDA receptor NR2B subunit.
| Project/Area Number |
19390309
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
SHIN Ryong-moon National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 (40443064)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Makoto 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10373359)
SUHARA Tetsuya 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, グループリーダー (90216490)
KANNO Iwao 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, グループリーダー (10360356)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 精神薬理学 |
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| Research Abstract |
We show that two distinct forms of LTP could be induced at amygdale synapses with an identical stimulation protocol depending on the level of postsynaptic membrane polarization. One form of LTP, resulting from pairing of postsynaptic depolarization and presynaptic stimulation, is induced by the activation of postsynaptic NMDA receptor, while same stimulation in the absence of postsynaptic depolarization leads to LTP, which is induced by the activation of presynaptic kainite receptor. There is a defined hierarchical order, such that presynaptic LTP is suppressed when postsynaptic LTP is induced by activation of CB1 receptors by endogenous cannabinoids released from postsynaptic cell. These results describe a previously unknown mechanism for the hierarchy of co-existing forms of LTP, possibly reflecting the hierarchy of memories for the previously experienced fearful events according to their aversiveness level.
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