2009 Fiscal Year Final Research Report
A prediction research of effect of the radiotherapy using molecular biology for the patients with cervical cancer
| Project/Area Number |
19390326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ARIMA Yoko Kansai Medical University, 医学部, 准教授 (80140276)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHIMA Hiromi 九州大学, 医学部, 教授 (40140917)
IMADA Hajime 産業医科大学, 医学部, 准教授 (50223326)
HIRAKI Yoshiyuki 鹿児島大学, 医学部, 講師 (90264423)
KAMATA Minoru 関西医科大学, 医学部, 助教 (00305195)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAKI Yoshiyuki 鹿児島大学, 医学部, 講師 (90264423)
KAMATA Minoru 関西医科大学, 医学部, 助教 (00305195)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 子宮頸癌 / 放射線 / 治療効果予測 / バイオマーカー / アポリポ蛋白C-II |
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| Research Abstract |
To determine the pretreatment serum protein level as a generally applicable measurement in predicting the radiation treatment effect of patients with cervical carcinoma (CC), we identified Apolipoprotein C-II (ApoC-II). Next, we have made Elisa-Kit by the monoclonal antibody of ApoC-II. And then we analyzed ApoC-II serum protein level of 65 examples with CC and correlation with cause-specific survival rate by Cox proportional-hazard model analysis. On univariate and multivariate analysis, ApoC-II was a significant independent predictor of poor cause-specific survival rate (p=0.01, p=0.02). The specificity and sensitivity of ApoC-II levels were 97.9% and 44.4%, respectively, as determined using ROC curves. ApoC-II could be used as a biomarker for detection in predicting the radiation treatment effect of patients with CC.
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[Journal Article] High-dose-rate Intracavitary Brachytherapy Combined with External Beam Radiotherapy for Stage IIIb Adenocarcinoma of the Uterine Cervix in Japan: A Multi-Institutional Study of Japanese Society of Therapeutic Radiology and Oncology 2006-2007 (Study of JASTRO 2006-2007).2010
Author(s)
Yuzuru Niibe, Masahiro Kenjo, Hiroshi Onishi, Yoshihiro Ogawa, Tomoko Kazumoto, Ichiro Ogino, Kayoko Tsujino, Yoko Harima, Takeo Takahashi, Akira Anbai, Emiko Tsuchida, Takafumi Toita, Mitsuhiro Takemoto, Hideomi Yamashita, Kazushige Hayakawa
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Journal Title
Jp J Clin Oncol (in press)
Peer Reviewed
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[Journal Article] 子宮頸癌の放射線単独療法、同時化学放射線療法に対するJROSG婦人科腫瘍委員会調査報告-2001年から2003年における子宮頸癌の同時化学放射線療法の実態調査-2009
Author(s)
中野隆史, 桜井英幸, 鈴木義行, 大野達也, 加藤真吾, 坂田耕一, 戸板孝文, 片岡正樹, 田中栄一, 兼安祐子, 宇野隆, 播磨洋子
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Journal Title
日本放射線学会第21回学術大会調査報告
Pages: 19-25
Peer Reviewed
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[Journal Article] 経皮的椎体形成術とその画像診断2009
Author(s)
米虫敦, 谷川昇, 狩谷秀治, 小島博之, 庄村裕三, 徳田貴則, 野村基雄, 池田耕士, 宇都宮啓太, 播磨洋子, 左野明, 澤田敏
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Journal Title
Peer Reviewed
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[Journal Article] Results of concomitant chemoradiation for cervical cancer using high dose rate intracavitary brachytherapy: Study of JROSG (Japan Radiation Oncology Study Group).2008
Author(s)
Sakata K, Sakurai H, Suzuki Y, Katoh S, Ohno T, Toita T, Kataoka M, Tanaka E, Kaneyasu Y, Uno T, Harima Y, Nakano T
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Journal Title
Acta Oncologica 47
Pages: 434-441
Peer Reviewed
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[Journal Article] Long-term tumor control of a fibrosarcoma inthe left lower extremity after thermoradiotherapy and limb-sparing surgical resection.2007
Author(s)
Atsumi K, Shioyama Y., Nomoto S, Ohga S, Yoshitake T, Toba T, Ohnishi K, Terashima H, Tanaka K, Matsuda S, Nakamura K, Iwamoto Y., Honda H
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Journal Title
Thermal Medicine 23
Pages: 145-151
Peer Reviewed
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