2009 Fiscal Year Final Research Report
Structures and Functions of the N-terminal Domains of SUMO Ligase PIAS/Siz Family
| Project/Area Number |
19570115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
YAMAZAKI Toshimasa National Institute of Agrobiological Sciences, タンパク質機能研究ユニット, ユニット長 (40360458)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINDO Heisaburo 独立行政法人農業生物資源研究所, タンパク質機能研究ユニット, 外来研究員 (80138966)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生物物理 / 蛋白質 / 分子認識 / SUMO化翻訳後修飾 / SUMOリガーゼ / DNA結合 / ヒストン認識 |
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| Research Abstract |
Post-translational modification of target proteins by SUMO regulates a wide variety of cellular functions. Among three enzymes (E1, E2 and E3) involved in the SUMO pathway, SUMO E3 ligases are thought to play important roles to recognize target proteins and facilitate their sumoylation. Here, we studied structures and functions of the N-terminal SAP and PHD of SUMO ligase PIAS/Siz family by NMR spectroscopy.
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Research Products
(5 results)
