2009 Fiscal Year Final Research Report
The mechanism of diabetic the neuropathic pain : Approach to novel drugs
| Project/Area Number |
19590265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
TAKANO Yukio Fukuoka University, 薬学部, 教授 (50113246)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Kenji 福岡大学, 薬学部, 助教 (60140761)
SAITO Ryo 福岡大学, 薬学部, 講師 (80122696)
MATSUSUE Kimihiko 福岡大学, 薬学部, 准教授 (10389364)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経因性疼痛 / 糖尿病 / ムスカリン受容体 / グリア細胞 / インスリン抵抗性 / peroxisome proliferator-activated receptor gamma |
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| Research Abstract |
(1) In this study, therefore, we examined the mechanism of diabetic neuropathic pain in detail. Especially, we demonstrated how the spinal muscarinic receptors and the ATP receptors involve in neuropathic pain. In addition, pre-administrations of microglia inhibitor minocycline inhibited the allodynia. (2) Peroxisome proliferator-activated receptor gamma (PPARgamma) is induced in leptin-deficient (ob/ob) mouse liver and is critical for the development of hepatic steatosis. We exanimed that fat-specific protein 27 (Fsp27) in ob/ob liver is a direct target gene of PPARgamma and can elevate hepatic triglyceride levels.
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[Journal Article] Aldosterone-sensitive NTS neurons regulate sensitivity of the baroreceptor reflex in high-sodium loaded rats2010
Author(s)
Masuda T, Hirabara Y, Nakamura Y, Chishaki A, Tsuruhisa M, Miyakawa M, Honda K, Saito R, Sakamoto H, Kawata M, TakanoY
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Journal Title
J. Pharmacol. Sci. 112
Pages: 482-486
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[Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype2008
Author(s)
Gang Zhu, M Okada, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S
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Journal Title
J. Neuroscience 28
Pages: 12465-12476
Peer Reviewed
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[Presentation] モデルラットにおいて動脈圧受容器反射は減弱する;弧束核におけるアルドステロン感受性神経2009
Author(s)
増田大治, 中村祐介, 宮川雅行, 平原康寿, 本多健治, 斎藤亮, 有森和彦, 中川裕之, 坂本浩隆, 河田光博, 高野行夫, 糖尿病・食塩負荷
Organizer
第82回日本薬理学会年会
Place of Presentation
横浜
Year and Date
20090300
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