2009 Fiscal Year Final Research Report
Identification of candidate proteins involved in synaptic plasticity by database search and experimental evaluations of their cellular functions
| Project/Area Number |
19700304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
CHIMURA Takahiko The Institute of Physical and Chemical Research, 記憶学習機構研究チーム, 研究員 (90392034)
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| Project Period (FY) |
2007 – 2009
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| Keywords | PDZ結合モチーフ / 神経可塑性 / バイオインフォマティクス / シグナル伝達 |
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| Research Abstract |
The followings were achieved by this project.
1. PDZ binding motifs are special sequence overrepresented at the C-terminal ends of proteins.
2. Using this information, novel interactions mediated PDZ binding motifs and PDZ domains were identified.
3. Novel membrane proteins expressed in neurons were identified. Interacting proteins with the intracellular portion of these proteins were identified.
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