Identification of substances and elucidation of mechanism of mode of action for the development of non-fungicidal controlling agent that destruction of biological control of plant pathogens

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K05769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38020:Applied microbiology-related
• Research Institution: Shimane University
• Principal Investigator: Ueno Makoto 島根大学, 学術研究院環境システム科学系, 教授 (00403460)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 植物病害防除 / 二次代謝産物 / イネ / いもち病

Outline of Final Research Achievements

In this study, it was clarified that the secondary metabolites of microorganisms preserved in the Okinawa microbial library can suppress the outbreak of the disease by acting on the appressorium of the rice blast fungus and infection site of other plant pathogenic fungi. In addition, it was clarified that the active substances contained in the secondary metabolites of microorganisms can be produced by several Streptomyces sp.. Also, it was high molecular weight substances that were stable against heat and acid. Furthermore, it was shown that this active substance may affect the expression of genes involved in the bioregulation of plant pathogenic fungus.

Free Research Field

植物病理学

Academic Significance and Societal Importance of the Research Achievements

化学合成農薬は植物病原菌の様々な部位に直接作用し、殺菌することで防除に貢献する。しかし、耐性菌の出現が問題であった。本研究では、植物病原菌の生体制御に関わる遺伝子に作用する微生物の2次代謝産物の生産方法と植物病原菌に対する作用機構の一部を明らかにできた。これらの結果は、遺伝子をターゲットした新たな作用的を示す農薬の開発に寄与できることを示した。今後、本物質が農薬として利用することができれば、農作物の安定的な生産に貢献できると考えられる。