2022 Fiscal Year Final Research Report
Anamysis of Hypoxic-ischemic Encephalopathy in commn marmosets.
| Project/Area Number |
19K08305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 周産期 / 低酸素 / 霊長類モデル / オリゴデンドロサイト / ミクログリア / 脳室周囲白質軟化症 |
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| Outline of Final Research Achievements |
In the perinatal area, premature infants remain at about 6% and are still the main cause of developmental disorders. It has been suggested to be associated with hypoxia/ischemia and inflammation in the perinatal period, and the generation and function suppression of oligodendrocytes are deeply involved.
In this study, we performed immunohistochemical staining of the periventricular white matter of perinatal primate marmoset neonates under stress using a hypoxic chamber. In the hypoxia-induced group, oligodendrocytes were significantly decreased in number along with the increase of teh Iba1 positive micrpoglia, suggesting differentiation of microglial cells were obtained.Findings suggestive of differentiation of microglial cells were obtained.
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| Free Research Field |
胎児・新生児医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果より、低酸素リスクの高い新生児では、低酸素状態により脳室周囲組織のオリゴデンドロサイトの発生抑制と炎症細胞であるミクログリアの分化が原因として存在することが明らかとなった。
今後、本研究の成果を元に、これらオリゴデンドロサイトの誘導ならびにマイクログリア活性化の抑制に向けた生直後からの新規薬物療法の開発を行いたい。
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