2022 Fiscal Year Final Research Report

Mutations for life lengthening of pancreatic cancer patients: mechanism and proposed theory for practice

Research Project

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Project/Area Number	19K08378
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 53010:Gastroenterology-related
Research Institution	Osaka Metropolitan University (2022) Osaka City University (2019-2021)
Principal Investigator	INOUE Akira 大阪公立大学, 大学院医学研究科, 研究員 (50109857)
Co-Investigator(Kenkyū-buntansha)	國本浩之大阪公立大学, 大学院医学研究科, 助教 (80372853) 山本直樹国際医療福祉大学, 基礎医学研究センター, 教授 (70312296) 中嶋弘一大阪公立大学, 大学院医学研究科, 特別研究員 (00227787)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	RBM10/S1-1 / splicing regulator / RBM10遺伝子変異と疾病 / 活動度の自己調節機構 / S1-1 nuclear body / 細胞分裂機構とRBM10 / 総説 RBM10 / Wikipedia (英語版)全面改訂
Outline of Final Research Achievements	Incorporating into the scientific research, A. Inoue reviewed biological importance of RBM10 gene, and its mutations and associated diseases in the journal GENE. The work confirmed logical correctness of the research subject and the aimed goal. The review has been well received: 23 lecture invitations from international conferences/meetings and 20 inauguration requests as editor or guest editor for special issues on RBM10 from various journals have been offered (as of Apr. 15, 2023). In addition, we published two RBM10 papers, which show the molecular and cellular importance of RBM10. One demonstrates the occurrence of suppressive self-regulatory mechanism for RBM10 to control its cellular activity, and the other shows that RBM10 is essential for normal cell division. However, the research project has not gone far enough as originally planned.
Free Research Field	分子生物学、細胞生物学
Academic Significance and Societal Importance of the Research Achievements	RBM10の総説執筆作業は本基盤研究の論理性と課題目標の正しさを改めて確認させるものとなった。総説は好評で、23の国際会議・学会からの講演招待や20の雑誌社からの編集委員あるはRBM10特集号のGuest Editorの就任依頼となっている。また、NCBIのデーターベースPubMedではRBM10論文群の最初に本総説が示され（現時点）、遺伝子部門（ヒトRBM10遺伝子）では主要論文５編の１つが本総説、もう１つはRBM10の自己調節機構を述べた我々の論文である。更にRBM10による細胞分裂の制御を発表。これら論文の学術的意義はRBM10の分子細胞生物学的特性を新たに明らかにした点にある。