2021 Fiscal Year Final Research Report
Elucidation of the relationship between bacterial colonization in the lower airway and the pathogenesis of severe asthma: a longitudinal and comprehensive study
| Project/Area Number |
19K08649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Kindai University (2021)
Kyoto University (2019-2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 功朗 京都大学, 医学研究科, 准教授 (40447975)
小熊 毅 京都大学, 医学研究科, 特定助教 (50601324)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 閉塞性気道疾患 |
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| Outline of Final Research Achievements |
The detection of Staphylococcus aureus in sputum in patients with bronchiectasis, including those with asthma complications, was associated with allergic inflammation and eosinophilic inflammation, potentially via enterotoxin sensitization. On the other hand, the distribution of allergic and eosinophilic inflammation was not identical. In cases of obstructive airway diseases, including severe asthma, high sputum occupancy of γ-Proteobacteria and Haemophilus spp. was associated with not only neutrophilic airway inflammation but also moderate eosinophilic/type 2 airway inflammation (mixed inflammation) and sputum symptoms.
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| Free Research Field |
呼吸器疾患
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では重症喘息を含む閉塞性気道疾患例で、喀痰中Proteobacterium綱（G陰性桿菌）の検出は好中球性炎症と関係することが確認されたが、中等度までの好酸球/2型炎症も併存すること、強い好酸球性炎症例ではG陰性桿菌定着が少ないこと、喀痰症状にはG陰性桿菌と好酸球性炎症がともに寄与することを明らかにした。近年重症喘息のみならず、COPDや気管支拡張症でも末梢血好酸球数が管理指標の一つとなってきたが、本研究結果は末梢血好酸球数の解釈も含め、閉塞性気道疾患の長期管理において重要な知見になると考えられる。
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