2021 Fiscal Year Final Research Report
Elucidation of organ-specific metastasis formation-promoting microenvironment focusing on metastatic organ-directedness of pancreatic cancer
| Project/Area Number |
19K09175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
寅田 信博 九州大学, 大学病院, 臨床検査技師 (00398075)
森山 大樹 九州大学, 大学病院, 准教授 (70586859)
大内田 研宙 九州大学, 大学病院, 講師 (20452708)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 膵癌 / desmoplasia / drug delivery system / ナノ粒子 |
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| Outline of Final Research Achievements |
Pancreatic cancer is characterized by abundant stroma. This prevents the delivery of therapeutic drugs to cancer cells by high tissue pressure and hypervascularity in the stroma, and the stroma acts as a physical barrier.
In this study, we developed a drug delivery system using nanoparticles that can specifically deliver drugs to the pancreatic cancer stroma. Furthermore, we succeeded in safely and reliably administering chloroquine, which has a regulatory effect on the stroma of pancreatic cancer, at a dose as low as one-fifth the usual dose in a mouse model. This system enables stromal control and, when combined with gemcitabine, has been shown to reduce the size of tumors.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
膵癌は発見時に進行しており、化学療法が必要となることが多いが、現在その効果は限定的である。その原因として薬剤送達の障壁となる間質増生が顕著であり、単に血流を介したdrug delivery systemでは十分な効果は得られていない。
本研究では、ナノ粒子によるdrug delivery systemを介してchloroquineを投与することで間質を制御しつつ、抗癌剤を投与することで効果を上昇させることに成功した。この手法を取ることで他の薬剤への応用も可能と考えられ、臨床的意義があるものと考える。
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