The development of Cardioprotection therapy with ischemic myocardium-homing peptide along with revascularization

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K09253
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Kanki Sachiko 大阪医科薬科大学, 医学部, 講師 (40411350)
• Co-Investigator(Kenkyū-buntansha): 三重野 繁敏 大阪医科薬科大学, 医学部, 非常勤講師 (10411373) ; 渡邊 房男 大阪医科薬科大学, 医学部, 功労教授 (40183719)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 虚血再灌流傷害 / 虚血組織送達 / 心筋細胞

Outline of Final Research Achievements

To improve mortality from ischemic heart failure, it is necessary to develop myocardial protection therapies aimed at maintaining and restoring function of injured myocardial tissue after myocardial ischemia. We have identified a peptide that accumulates specifically in ischemic myocardial tissue (Ischemic Myocardium Targeting Peptide: IMTP), which could be used to deliver drugs to ischemic myocardial tissue. This group of substances may be involved in the mechanism of tissue affinity. In this study, we were able to establish culture conditions that mimic ischemic conditions in vitro and will examine the conditions for drug delivery of IMTP peptides in the future.

Translated with DeepL.com (free version)

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

虚血傷害組織のみを標的とする心筋保護治療薬の開発が期待される。