The effects of neurotrophic factor for carbon monoxide poisoning–induced delayed encephalopathy

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K09436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Ehime University
• Principal Investigator: Nishihara Tasuku 愛媛大学, 医学系研究科, 准教授 (50568912)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 一酸化炭素中毒 / 遅発性脳症 / マイクログリア / 神経栄養因子 / IGF-2

Outline of Final Research Achievements

In caarbon monoxide (CO) poisoning, decreased in microglial cell numbers are observed and microglia (MG) with detached branches are observed. Furthermore, mRNAs encoding several neurotrophic factors expressed by MG were decreased. These findings may cause delayed encephalopathy (DE). We aimed that supplementation of Insulin-like growth factor-2(IGF-2) may prevent DE. As the results, supplementation of IGF-2 prevented demyelination but was not associated with survival of MG. Moreover, IGF-2 ameliorated CO induced behavioral abnormality. These effects are probably induced via IGF-1 receptor expressed on the neuronal cell surface. Supplementation of IGF-2 may have certain effects on DE after CO poisoning.

Free Research Field

神経免疫

Academic Significance and Societal Importance of the Research Achievements

これまで一酸化炭素中毒およびその後遺症ともいえる遅発性脳症に対して、明らかに有効といえる治療方法はなかった。しかしながら、本研究により、IGF-2という神経栄養因子の補充が、中毒後に介入可能な治療方法として可能性が認められたことは、大きな進歩といえる。