• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2022 Fiscal Year Final Research Report

The effects of neurotrophic factor for carbon monoxide poisoning–induced delayed encephalopathy

Research Project

  • PDF
Project/Area Number 19K09436
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionEhime University

Principal Investigator

Nishihara Tasuku  愛媛大学, 医学系研究科, 准教授 (50568912)

Project Period (FY) 2019-04-01 – 2023-03-31
Keywords一酸化炭素中毒 / 遅発性脳症 / マイクログリア / 神経栄養因子 / IGF-2
Outline of Final Research Achievements

In caarbon monoxide (CO) poisoning, decreased in microglial cell numbers are observed and microglia (MG) with detached branches are observed. Furthermore, mRNAs encoding several neurotrophic factors expressed by MG were decreased. These findings may cause delayed encephalopathy (DE). We aimed that supplementation of Insulin-like growth factor-2(IGF-2) may prevent DE. As the results, supplementation of IGF-2 prevented demyelination but was not associated with survival of MG. Moreover, IGF-2 ameliorated CO induced behavioral abnormality. These effects are probably induced via IGF-1 receptor expressed on the neuronal cell surface. Supplementation of IGF-2 may have certain effects on DE after CO poisoning.

Free Research Field

神経免疫

Academic Significance and Societal Importance of the Research Achievements

これまで一酸化炭素中毒およびその後遺症ともいえる遅発性脳症に対して、明らかに有効といえる治療方法はなかった。しかしながら、本研究により、IGF-2という神経栄養因子の補充が、中毒後に介入可能な治療方法として可能性が認められたことは、大きな進歩といえる。

URL: 

Published: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi