Investigation of CNS related pain inhibitory mechanisms for vibratory stimulus in fibromyalgia model mice

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kumamoto Health Science University
• Principal Investigator: Doi Atsushi 熊本保健科学大学, 保健科学部, 教授 (60619675)
• Co-Investigator(Kenkyū-buntansha): 申 敏哲 熊本保健科学大学, 保健科学部, 教授 (70596452)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 線維筋痛症 / 運動療法 / 振動刺激 / 心電図 / 中枢神経

Outline of Final Research Achievements

We investigated the effect of pool gait exercise using fibromyalgia model mice. The fibromyalgia model mice were randomly classified into two groups as follows: the control group and the pool gait group. Both groups underwent sensory thresholds and video recordings to determine locomotive behaviors weekly. Further, both heart rate and video recordings for observation of a recovery after the gait test in shallow water were undertaken. The pool gait did not affect sensory thresholds and locomotive behavior; however, in the pool gait group, both the recovery after the test, such as onset time and gait distance, were considerably better than those of the control group. Furthermore, changes in heart rate and heart rate irregularity after the test were more apparent in the control group than in the pool gait group. The free gait in a shallow pool accelerated recovery after exercise, unlike the sensory threshold.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

線維筋痛症患者の主症状と言えば、全身の筋肉痛である。しかしながら、その原因の一つとして中枢神経系及び末梢神経系のモノアミンに変化が生じているとすれば、運動負荷時に、心肺機能へ悪い影響が出てくる可能性がある。医療現場のスタッフには運動器や痛みの専門家が在籍しているかもしれないが、循環器疾患に精通した医療スタッフまたはトレーナーによって線維筋痛症患者の心肺機能を十分にモニタリングしながら、効果的なリハビリテーションを進めていく必要を非常に感じている。そのような意味で動物を用いた本研究の意義はあるのではないかと考えている。